INTRODUCTION


Research and Development Student Assosiation atau yang disingkat RDSA adalah sebuah lembaga penelitian dan pengabdian masyarakat yang resmi berdiri pada Juli 2012 di Institut Ilmu Kesehatan Kediri, Jawa Timur, Indonesia. Lembaga ini memiliki kegiatan pokok berupa penelitian yang dilakukan sendiri oleh mahasiswa. Tujuan didirikannya lembaga ini adalah untuk memfasilitasi mahasiswa dalam melakukan penelitian, yang nantinya penelitian tersebut diikutsertakan dalam berbagai kompetisi nasional maupun internasional. Saat ini anggota dari lembaga ini masih terbatas pada mahasiswa S1 Farmasi dan sebagian mahasiswa DIV Analis Kesehatan Institut Ilmu Kesehatan Bhakti Wiyata Kediri. Total anggota adalah 30 orang. Struktur kepengurusan RDSA adalah sebagai berikut :
Chief of RDSA                       : Chandra Arifin (S1 Farmasi 2010)
Secretary                                 : Nur Kumalasari (S1 Farmasi 2010)
Treasurer                                 : Rika Martiana (S1 Farmasi 2010)
Education and Training          : Panji Ratih Suci (S1 Farmasi 2010)
Research Methode                  : Fathul Hidayatul H. (DIV Analis 2010)
                                                  Maria Platonia D. Meo (S1 Farmasi 2010)
Submission Society                 : Nuril Anwari (S1 Farmasi 2010)
                                                 Cita Dwi Feri I. (S1 Farmasi 2010)
Tech. Research                        : Reka Wardani ( S1 Farmasi 2010)
Public Relation                        : Priskilia Dessy Ratnasari (S1 Farmasi 2010)
                                                  Yeyen Nor Fitriani (S1 Farmasi 2010)
           
Agenda kompetisi yang diikuti pada tahun 2013 ini adalah sebagi berikut :
1.      The 3rd International Conference on Pharmacy and Advanced Pharmaceutical Sciences (ICPAPS 2013) yang diadakan oleh Fakultas Farmasi Universitas Gadjah Mada (18-19 Juni 2013).
Penelitian yang dikirim untuk oral presentation :
COMPARISON OF REDUCTION BLOOD GLUCOSE LEVELS OF LEAVES AND PULP INDONESIAN Manilkara zapota (L.)
            Disusun oleh : Maria Platonia D. Meo dan Nuril Anwari
            Penelitian yang dikirim untuk poster presentation :
            INFLUENCE OF CILEMBU BULBS ON CHOLESTEROL LEVELS THE WHITE MICE (Mus musculus) IN VIVO
            Disusun oleh : Anis Susanti
           
QUALLITY OF LIFE MEASUREMENT IN HEART FAILURE PATIENTS THERAPY AND TOTAL COST MEDICATION”
Disusun oleh : Fita Sari

“EVALUATION PROTEIN ANTIOXIDANT OF Theobroma cacao DURING PROCESSING”
            Disusun oleh : Laili Indah M.
           
     BLOOD GLUCOSE AND TOTAL CHOLESTEROL CONTENT OF HYPERGLICEMIC WHITE MICE (MUS MUSCULUS) AFTER ORALLY INTAKES JUICE OF (CITRUS AURANTIFOLIA SWINGLE)”
            Disusun oleh : Fridyani Mita Ristiana
            Abstrak penelitian untuk ICPAPS bisa diliat pada postingan sebelumnya.
2.      Pemilihan Peneliti Remaja Indonesia (PPRI) Ke-12 Tahun 2013 yang diadakan oleh Lembaga Ilmu Pengetahuan Indonesia (September 2013).
3.      2013 Annual Conference & Exhibition Functional Foods, Nutraceuticals, Natural Health Products and Dietary Supplements. Howard Civil Service International House, Taipei, Taiwan (November 5-9, 2013).

Alhamdulillah semua penelitian yang dikirim ke ICPAPS 2013 berhasil lolos untuk oral presentation dan poster presentation. Fighting!!

INFLUENCE OF CILEMBU BULBS ON CHOLESTEROL LEVELS THE WHITE MICE (Mus musculus) IN VIVO



ABSTRACT

INFLUENCE OF CILEMBU BULBS ON CHOLESTEROL LEVELS THE WHITE MICE (Mus musculus) IN VIVO

Anis Susanti(1), Cikra Ikhda N.H.S (2), Dewy Resty B (3)
Departement of Biology Pharmacy, IIK, Kediri, Indonesia
Email : cikranursanianto@yahoo.com


Increased levels of cholesterol in the blood is a major cause of atherosclerosis. This study aimed to examine the effect Cilembu bulbs that can lower cholesterol levels in experimental Mus musculus were induced by High Fat Diet Eat (MDLT) consisting of oil and beef fat with a ratio of  5:1 which aims to optimize cholesterol levels blood of mice. 30 research subjects mice. This experiment was divided into 6 groups: negative control (PGA 2% BB), positive control (MDLT 2% BB), comparison (2% + simvastatin MDLT 0.026 mg / 20 g BW), and 3 different doses (0.5 , 2, 5 mg / 20 g BW). Total blood cholesterol levels of tail measured by Glico test. Data were analyzed by repeated ANOVA, followed by Duncan test. The tubers Cilembu significant effect on lowering blood cholesterol levels (p <0,05).
Results of this study showed that infusion at a dose of 0.5 Cilembu bulbs, 2, 5 mg/20 g BW mice can lower total cholesterol. Decrease in total cholesterol levels by 21,27% concentration can lower total cholesterol levels were the highest obtained in mice given Cilembu tuber infusion at a dose of 5 mg/20 g BW.

Keywords: bulbs Cilembu, total cholesterol, Mus musculus

Blood glucose and total cholesterol content of hyperglicemic white mice (Mus musculus) after orally intakes Juice of (Citrus aurantifolia Swingle)


ABSTRACT

Blood glucose and total cholesterol content of hyperglicemic white mice (Mus musculus) after orally intakes Juice of (Citrus aurantifolia Swingle)

Fridyani Mita R(1), Cikra Ikhda N.H.S.,S.Farm, M.Si, Apt(2), Dewy Resty B.,S.Farm, Apt(3)
Departement of Pharmaceutical Biology-IIK-Kediri-Indonesia
Email : Cikranursanianto.yahoo.com

The main symtomp of diabetes mellitus is an increase of blood glucose concentration, therefore it can be decreased using natural subtances. The research aimed to the juice of Citrus aurantifolia Swingle can decrease the concentration of blood glucose and total cholesterol content in Mus musculus. The subjects were 25 Mus musculus of BalB/cAnN starin. The chemical subtance used to increase the concentration of blood glucose  was 1 cc/kb BB of dextrose monohidrat 10%. The animals were devided into 6 groups that are threaded by giving : negative control (CMC 1%, 1 ml/20 g BB), positiv control (glibenclamid 0,013 mg/20 g BB), juice of Citrus auratifolia Swingle in various concentration (0,5, 2, 5 mg/20 g BB). The concentration of blood  glucose and total cholesterol content was measured using glico test. The data gained were analyzed using repetead ANOVA followed by Duncan at 5% confidence level. The results of this research shows that the of Citrus aurantifolia Swingle giving significant effect on the reduction of blood glucose (p<0,05), however it does not appear to have the same result to total cholesterol content. At various concentration of Citrus aurantifolia Swingle, the total cholesterol of rat remain stable. The optimum concentration to provide hypoglicemic activity raised at 2 mg/ 20 g BB dose.

Keywords : Citrus aurantifolia Swingle, blood glucose, total cholesterol content.

QUALLITY OF LIFE MEASUREMENT IN HEART FAILURE PATIENTS THERAPY AND TOTAL COST MEDICATION


QUALLITY OF LIFE MEASUREMENT IN HEART FAILURE PATIENTS THERAPY AND TOTAL COST MEDICATION
Fita 1)*, Cikra 2)*
InstitutIlmuKesehatan, Kediri, Indonesia
email : cikranursanianto@yahoo.com

ABSTRACT

Heart failureis a complex syndrome associated with increased mortality, hospitalization, and poor quality of life. This research was conducted to assessthe quality of life heartfailure patients with patients conditions.
In this study was involved 28 people with heart failure are treated in hospitals. Evaluation quality of life heart failure patients using a method  Heart Relation Quality of Life (HRQoL), the anallyzed among Heart Relation Quality of Life (HRQoL) with socio-demographic, degree of severity byNew York Heart Association (NYHA), the characteristics of therapy, and total cost of treatment was anallyzed using spearmank corellation that was continued bivariateand multivariate anallyzed between the independent variables.
The results of demographic characteristics the study showed that most patients with heart failure  the research subjectsbe male(67,9%), agerange45-59years(9%), education level of elementary school(60,7%), work that dominates the study subjects were farmers(39.3%). The degree severity ofNYHA most  the subjects included in the NYHA class III(60.7%). The therapy that gotten show suitable (64,3%) with the terapy characteristics of the most commonly used diuretic-furosemide(25.8%). The combination therapyof heart failure is the most widely useddrug in combination with 3 heart failure are Diuretics-Nitrates-Digoxinas many(13.3%), and a combination of 4 drugs, namely heart  failure Diuretics-Aldosteroneantagonists-ARB-Inotropic as many (13,3%). The total cost of treatment heart failure patients with comorbid greater costs(13,3%) with total costis Rp 2.151.194±30.361. The corellation anallyze show that education, gender, and severity by NYHAis an independent variable affects the quality of life heart failure patients.
Key word : HRQoL, heart failure, therapy, total cost