Abstract : COMPARISON OF REDUCTION BLOOD GLUCOSE LEVELS OF LEAVES AND PULP INDONESIAN Manilkara zapota (L.)

COMPARISON OF REDUCTION BLOOD GLUCOSE LEVELS OF LEAVES AND PULP INDONESIAN Manilkara zapota (L.)

Maria Platonia*, Nuril Anwari**, Cikra INHS ***

* Faculty of Pharmacy, Institut Ilmu Kesehatan Bhakti Wiyata Kediri, Indonesia ,

** Faculty of Pharmacy, Institut Ilmu Kesehatan Bhakti Wiyata Kediri, Indonesia ,

*** *Departement of Biology Pharmacy, Faculty of Pharmacy, Institut Ilmu Kesehatan Bhakti Wiyata Kediri, Indonesia ,

E-mail : Cikranursanianto@yahoo.com

Abstract

            Indonesian Manilkara zapota (sawo) is a tropical plant that generally grows various regions in Indonesia. Based on the last research, Manilkara zapota leaves potential as an antioxidant and antihyperglycemic. Indonesian Manilkara zapota (sawo) fruit is often consumed in everyday and have glucose content. The objective of this research is to determine the potential hypoglycemic effect of  both leaves or pulp Indonesian Manilkara zapota and then compare blood glucose level after induced with dextrose 10%.

The method research was real experiment. Extracted leaves using Soxhletasi  with ethanol and the pulp using juice made ​​with each concentration of and 0.5g/kg b.w., 1.3 g/kg b.w., 10 g/kg b.w., 20 g/kg b.w., 30 g/kg b.w. Experimental animals were divided into five groups (n = 5). Group I (negative control), group II (fruit juice 1.3 g/kg b.w), III (fruit juice 0.5 g/kg b.w), IV (leaf extract 0.5 g/kg b.w) and V  (leaf extract 1.3 g / kg b.w). The data is taken two hours after giving of the extract and then every 60 minutes for 4 hours. Analized this comparison using T-Test (SPSS Vers 17,0).  

Based on study showing different content of total protein, fenolik and flavonoid of the leaves and pulp. From the calculation of blood glucose level percentage administration significant difference between group. Dose 0,5 g/kg b.w of The Leaves and pupl not showing significant difference with blood glucose lowering effect. The result this research that antihyperglycemic activity of  both leaves or pulp start from dose 1,3 g / kg b.w have effective effect to decreased blood glucose. From this research knowing that dose of leaves  1,3 g/kg b.w have blood glucose lowering effect than pulp (p<0.05). At dose 30 g/kg b.w the pulp decreased blood glucose 83% while the leaves only give 22%. So at dose 30 g/kg b.w of pulp have blood glucose higher effect than leaves at the same dose.

Keyword :  Indonesian  Manilkara zapota, Hyperglycemic, leaves, pulp