ABSTRACT
Blood
glucose and total cholesterol content of hyperglicemic white mice (Mus
musculus) after orally intakes Juice of (Citrus aurantifolia Swingle)
Fridyani Mita R(1), Cikra
Ikhda N.H.S.,S.Farm, M.Si, Apt(2), Dewy Resty B.,S.Farm, Apt(3)
Departement of Pharmaceutical
Biology-IIK-Kediri-Indonesia
Email : Cikranursanianto.yahoo.com
The
main symtomp of diabetes mellitus is an increase of blood glucose
concentration, therefore it can be decreased using natural subtances. The
research aimed to the juice of Citrus aurantifolia Swingle can decrease the
concentration of blood glucose and total cholesterol content in Mus musculus.
The subjects were 25 Mus musculus of BalB/cAnN starin. The chemical subtance
used to increase the concentration of blood glucose was 1 cc/kb BB of dextrose monohidrat 10%.
The animals were devided into 6 groups that are threaded by giving : negative
control (CMC 1%, 1 ml/20 g BB), positiv control (glibenclamid 0,013 mg/20 g
BB), juice of Citrus auratifolia Swingle in various concentration (0,5, 2, 5
mg/20 g BB). The concentration of blood
glucose and total cholesterol content was measured using glico test. The
data gained were analyzed using repetead ANOVA followed by Duncan at 5%
confidence level. The results of this research shows that the of Citrus
aurantifolia Swingle giving significant effect on the reduction of blood
glucose (p<0,05), however it does not appear to have the same result to
total cholesterol content. At various concentration of Citrus aurantifolia
Swingle, the total cholesterol of rat remain stable. The optimum concentration
to provide hypoglicemic activity raised at 2 mg/ 20 g BB dose.
Keywords : Citrus aurantifolia Swingle, blood
glucose, total cholesterol content.
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